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Chronic cerebrospinal venous insufficiency in patients with multiple sclerosis
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  • Published on:
    MS appears to be related to venous flow abnormality of the brain with secondary brain autoimmunity

    Dear Editor,

    I read the article by Zomboni (1) with interest, with respect to the interaction of the cerebral venous system and central nervous system in development of multiple sclerosis (MS).

    An interaction between the central nervous system and venous system has been observed previously in MS lesions by F. A Schelling (2) who initially observed “striking widening of the main venous passageways in t...

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    Conflict of Interest:
    None declared.
  • Published on:
    Chronic cerebrospinal venous insufficiency: a potential weakening factor of the blood-brain barrier

    Dear Editor,

    Multiple sclerosis is believed to be an autoimmune pathology, yet the mechanisms triggering the disease remain elusive. Therefore, I read with great interest the paper by Zamboni and his team who investigated the venous hemodynamics in patients with multiple sclerosis. His findings that this disease might be attributable to venous refluxes shed new light on the facts that have been known for decades...

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    Conflict of Interest:
    None declared.