Article Text

Download PDFPDF
Definite multiple system atrophy in a German family
  1. U Wüllner1,
  2. I Schmitt1,
  3. M Kammal2,
  4. H A Kretzschmar3,
  5. M Neumann3
  1. 1
    Department of Neurology, University Bonn, Bonn, Germany
  2. 2
    Department of Legal Medicine, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany
  3. 3
    Center for Neuropathology and Prion Research, Ludwig-Maximilians University, Munich, Germany
  1. Dr U Wüllner, Department of Neurology, University Bonn, Sigmund Freud Str. 25, D-53105 Bonn, Germany; wuellner{at}

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

Multiple system atrophy (MSA) is a presumed sporadic neurodegenerative disorder of unknown aetiology, clinically characterised by poorly levodopa responsive parkinsonism and/or cerebellar dysfunction in combination with autonomic failure.1 We previously identified a family with a typical MSA phenotype in two successive generations.2 One affected patient of that pedigree, now deceased at age 82, and postmortem examination of the brain revealed findings typical of definite MSA.3 Severe atrophy of the putamen (fig 1A) and depigmentation of the substantia nigra and pontine and cerebellar atrophy were found upon macroscopic …

View Full Text


  • Competing interests: None.

  • Funding: This study was supported by the Kompetenznetz Parkinson (01G19901), NGFN (01GS0115, NV-SO2T9), the BONFOR Program of the University Bonn the German Brain Bank (01GI0505) and the “Deutsche Parkinson Vereinigung.”

  • Patient consent: Obtained.