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Prospective study of chemical exposures and amyotrophic lateral sclerosis
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    Neurotoxicity of formaldehyde

    Dear Editor,

    Although the association of the formaldehyde exposure with the etiology of ALS may be due to bias, the careful investigation of Weisskopf et al. (1) is thought-provoking.

    Methanol and its first metabolite are neurotoxic (2, 3) because their common end metabolite formic acid is an inhibitor of the cytochrome oxidase in the mitochondrial respiratory chain (3).

    The neurochemical mech...

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    Conflict of Interest:
    None declared.