Article Text

Download PDFPDF
Deep brain stimulation activation volumes and their association with neurophysiological mapping and therapeutic outcomes
  1. C B Maks1,
  2. C R Butson1,
  3. B L Walter2,
  4. J L Vitek2,3,
  5. C C McIntyre1,2
  1. 1
    Department of Biomedical Engineering, Cleveland Clinic Foundation, Cleveland, Ohio, USA
  2. 2
    Center for Neurological Restoration, Cleveland Clinic Foundation, Cleveland, Ohio, USA
  3. 3
    Department of Neurosciences, Cleveland Clinic Foundation, Cleveland, Ohio, USA
  1. Dr C C McIntyre, Department of Biomedical Engineering, Cleveland Clinic Foundation, 9500 Euclid Ave ND20, Cleveland, OH 44195, USA; mcintyc{at}


Objective: Despite the clinical success of deep brain stimulation (DBS) for the treatment of Parkinson’s disease (PD), little is known about the electrical spread of the stimulation. The primary goal of this study was to integrate neuroimaging, neurophysiology and neurostimulation data sets from 10 patients with PD, unilaterally implanted with subthalamic nucleus (STN) DBS electrodes, to identify the theoretical volume of tissue activated (VTA) by clinically defined therapeutic stimulation parameters.

Methods: Each patient specific model was created with a series of five steps: (1) definition of the neurosurgical stereotactic coordinate system within the context of preoperative imaging data; (2) entry of intraoperative microelectrode recording locations from neurophysiologically defined thalamic, subthalamic and substantia nigra neurons into the context of the imaging data; (3) fitting a three dimensional brain atlas to the neuroanatomy and neurophysiology of the patient; (4) positioning the DBS electrode in the documented stereotactic location, verified by postoperative imaging data; and (5) calculation of the VTA using a diffusion tensor based finite element neurostimulation model.

Results: The patient specific models show that therapeutic benefit was achieved with direct stimulation of a wide range of anatomical structures in the subthalamic region. Interestingly, of the five patients exhibiting a greater than 40% improvement in their Unified PD Rating Scale (UPDRS), all but one had the majority of their VTA outside the atlas defined borders of the STN. Furthermore, of the five patients with less than 40% UPDRS improvement, all but one had the majority of their VTA inside the STN.

Conclusions: Our results are consistent with previous studies suggesting that therapeutic benefit is associated with electrode contacts near the dorsal border of the STN, and provide quantitative estimates of the electrical spread of the stimulation in a clinically relevant context.

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.


  • Funding: This work was supported by grants from the Ohio Biomedical Research and Technology Transfer Partnership, Wallace H Coulter Foundation and National Institutes of Health (NS050449, NS052042 and NS059736).

  • Competing interests: CBM, CRB and CCM authored intellectual property related to the project methodology. CRB and CCM hold company shares in IntElect Medical Inc.

  • Ethics approval: This study was approved by the Cleveland Clinic Institutional Review Board.