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  • Effect of mannitol and hypertonic saline on cerebral oxygenation in patients with severe traumatic brain injury and refractory intracranial hypertension

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Effect of mannitol and hypertonic saline on cerebral oxygenation in patients with severe traumatic brain injury and refractory intracranial hypertension
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  • Published on: 8 April 2009
    The differences of osmotic effects between intact and disrupted Blood Brain Barrier
    • Kao-Chang Lin, Neurology, MD
    • Other Contributors:
      • Jinn-Rung Kuo, MD

    Dear Editor,

    This finding that given of 7.5% Hypertonic Saline (HTS) had better effects to decline the refractory intracranial hypertension (IICP) than Mannitol therapy (1) with which most physicians considered it as the first -line to have osmotic diuresis. The authors stated that HTS had several effects beyond cerebral blood flow (CBF) and oxygenation in patients with severe traumatic brain injury (TBI), and t...

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    Conflict of Interest:
    None declared.