Research paper
Long-term effects of childbirth in MS
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  • Published on:
    Evidence seriously flawed due to survival-related biases and confounding
    • Igor Karp, Assistant Professor
    • Other Contributors:
      • Alexandra Manganas

    We read with great interest a recent article by D'hooghe et al. (1) on long-term effects of childbirth on MS. Unfortunately, the study appears to have been subject to important biases (in addition to those discussed by the authors themselves, including, notably, confounding).

    The first bias - namely, the left-truncation bias (2) - has to do with the fact that to be included in the analyses, patients had to be "...

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    Conflict of Interest:
    None declared.