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The role of DAT-SPECT in movement disorders
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  • Published on:
    Re:DAT-SPECT. All that glitters is not gold.
    • Eduardo Tolosa, Dr.
    • Other Contributors:
      • Georg Kaegi and Kailash Bhatia
    We wish to thank Dr. Morrish for his comments to our review. He argues in his letter that for diagnostic purposes a technique needs to be sensitive to the disease and reproducible and that DAT-SPECT unfortunately falls down on each. Sensitivity is poor, he says, since DAT-SPECT imaging has been found to be normal in about 5 to 15% of individuals with parkinsonism. Such individuals ( SWEDDs ("scans without evidence of dopaminergic...
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    Conflict of Interest:
    None declared.
  • Published on:
    DAT-SPECT. All that glitters is not gold.

    Kagi and colleagues (1) provide a review but not a critique of a controversial technique. For a technique to have diagnostic utility it needs sensitivity to the disease and reproducibility; DAT-SPECT unfortunately falls down on each. The review describes the test as around 100% sensitive as a diagnostic tool in detecting PD. The authors conclude that the normal scans in 5-15% of patients with de-novo PD are normal becau...

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    Conflict of Interest:
    None declared.