Smoking and the risk of amyotrophic lateral sclerosis: a systematic review and meta-analysis
Compose Response

Plain text

  • No HTML tags allowed.
  • Web page addresses and e-mail addresses turn into links automatically.
  • Lines and paragraphs break automatically.
Author Information
First or given name, e.g. 'Peter'.
Your last, or family, name, e.g. 'MacMoody'.
Your email address, e.g.
Your role and/or occupation, e.g. 'Orthopedic Surgeon'.
Your organization or institution (if applicable), e.g. 'Royal Free Hospital'.
Statement of Competing Interests


  • Responses are moderated before posting and publication is at the absolute discretion of BMJ, however they are not peer-reviewed
  • Once published, you will not have the right to remove or edit your response. Removal or editing of responses is at BMJ's absolute discretion
  • If patients could recognise themselves, or anyone else could recognise a patient from your description, please obtain the patient's written consent to publication and send them to the editorial office before submitting your response [Patient consent forms]
  • By submitting this response you are agreeing to our full [Response terms and requirements]

Vertical Tabs

Other responses

  • Published on:
    Smoking and Exercise in Combination may adversely affect mitochondrial function and cause ALS in susceptible individuals

    I read the article by Alonso on smoking and risk of amyotrophic lateral sclerosis (ALS) with interest (1) While the meta-analysis may not support a strong association with smoking and ALS, there may be a relationship with the combination of smoking and exercise. Smoking increases carbon monoxide (CO) levels (2) and cyanide (3) in the blood. Cyanide binds with cytochrome oxidase in the mitochondria, and CO interferes wi...

    Show More
    Conflict of Interest:
    None declared.