Article Text


Estimating the impact of stroke unit care in a whole population: an epidemiological study using routine data
  1. Peter Langhorne1,
  2. James D Lewsey2,
  3. Pardeep S Jhund1,
  4. Michelle Gillies2,
  5. Jim W T Chalmers3,
  6. Adam Redpath3,
  7. Andrew Briggs2,
  8. Matthew Walters1,
  9. Simon Capewell4,
  10. John J V McMurray1,
  11. Kate MacIntyre2
  1. 1Cardiovascular and Medical Sciences Division, University of Glasgow, Glasgow, UK
  2. 2Section of Public Health and Health Policy, University of Glasgow, Glasgow, UK
  3. 3Information Services Division, Edinburgh, UK
  4. 4Department of Public Health, University of Liverpool, Liverpool, UK
  1. Correspondence to Professor P Langhorne, Academic Section of Geriatric Medicine, Level 3 University Block, Royal Infirmary, Glasgow G31 2ER, UK; p.langhorne{at}


Background and purpose Randomised trials indicate that organised inpatient (stroke unit) care has an important impact on patient outcomes with an absolute risk difference (ARD) of 3% for survival and 5% for returning home. However, it is unclear what impact this complex intervention actually has in routine practice. A comprehensive national dataset was used to study the impact of stroke unit implementation.

Methods The Scottish linked discharge database was used to identify all patients admitted to hospital with an incident stroke. Analyses compared case fatality and discharge home (adjusted for age, sex, deprivation and comorbidity) for hospitals with or without a stroke unit during four consecutive study periods: 1986–1990, 1991–1995, 1996–2000 and 2001–2005.

Results During the study period, the percentage of admissions to hospitals that had a stroke unit increased from 0% to 87%, the 6 month case fatality decreased from 45% to 29% and discharges home increased from 46% to 59%. Adjusted ORs (95% CI) for case fatality (stroke unit versus no unit) in each study period were as follows: not calculable (no units before 1991), 0.83 (0.78–0.89), 0.90 (0.86–0.94) and 0.87 (0.82–0.91). These equate to an ARD of 3.0% over the whole study period. Equivalent data for discharge home indicated an increased odds of discharge home: not calculable, 1.23 (1.15–1.31), 1.15 (1.10–1.21) and 1.17 (1.11–1.23) with an overall ARD of 5%.

Conclusions These results indicate a positive impact of a policy of stroke unit care on case fatality and discharge home. The estimated impact, after adjusting for case mix, appears very similar to that calculated using clinical trial data.

Statistics from


Organised inpatient (stroke unit) care has been shown to be effective in randomised trials. Patients who are managed within a stroke unit are more likely to survive, return home and regain independence.1 However, organised stroke unit care is a complex intervention with many facets that are difficult to define and replicate.2 This raises challenges and uncertainties when implementing into routine services. Also, randomised trials are often carried out under unusual controlled conditions and may not be easily reproduced in routine practice. Some of these potential concerns about implementing stroke unit care were addressed by a systematic review of observational studies which suggested that stroke units may have a similar effect on case fatality when applied in more routine care settings.3 However, this review identified a number of study limitations, including incomplete casemix adjustment, limited definition of service characteristics, possible selective admission to stroke units and short study periods.

Therefore, important uncertainties remain about several issues. Firstly, does the benefit of stroke unit care extend across a broad range of stroke patients, in particular those with a poorer prognosis who make the largest contribution to stroke related death and disability? Secondly, there might be the selective admission of patients to stroke units that produces a biased (favourable) estimate of benefit. Casemix adjustment may not completely compensate for this bias. Finally, most studies have used a rather informal, self-defined description of stroke unit care, which has not been externally validated.

This current study arose from the unique opportunities within Scotland to use comprehensive linked hospital discharge data (collected over a 20 year period) to study the association between well characterised hospital services outcome (case fatality and discharge home) of stroke patients. The study allowed us to explore changes in outcome during the period in which stroke units moved from being non-existent (prior to 1990) to being recommended in clinical practice guidelines (in 1995),4 and finally being established within the government health strategy (in 2002).5


Scotland has a population of 5.1 million and an estimated annual number of strokes in excess of 10 000 per annum, of whom the majority are admitted to hospital.5

The Information Services Division of the National Health Service in Scotland collects data on all discharges in National Health Service hospitals using the Scottish Morbidity Record (SMR) Scheme. Data from patient case records are used to code up to six diagnoses at the time of discharge according to the WHO Classification of Diseases (ICD 9 prior to 1996, ICD 10, after 1996). The term ‘discharge’ includes both live discharges and deaths. These data routinely link to information held by the General Register Office for Scotland that records information relating to all deaths in Scotland, including those that occur in individuals not previously hospitalised.

We identified all hospitalisations in Scotland for the period 1981–2005 where stroke was coded as the principal (first position) diagnosis at discharge. The following ICD9 and ICD10 codes were used to identify stroke (ICD10 codes in italics): 430 (subarachnoid haemorrhage), 431 (intracerebral haemorrhage), 433 (occlusion and stenosis of precerebral arteries), 434 (occlusion of cerebral arteries), 436 (acute, but ill defined cerebrovascular disease), I60 (subarachnoid haemorrhage), I61 (intracerebral haemorrhage), I63 (cerebral infarction), I64 (stroke, not specified as haemorrhage or infarction). Further detail on how incident stroke was defined is described elsewhere.6 SMR identifies stroke with an accuracy of 95% when the stroke code is recorded in the principle diagnostic position (Information Services Division Data Quality Assurance). A number of comorbidities were identified and recorded as in previous publications.6 These included principal and secondary diagnoses for any previous hospitalisations in the last 5 years and secondary diagnoses recorded in the incident stroke hospitalisation: diabetes, cancer, respiratory disease, heart failure, peripheral arterial disease, atrial fibrillation essential hypertension, renal failure, coronary artery disease, valvular heart disease, venous thromboembolism, obstructive sleep apnoea, depression, parkinsonism, dementia, falls and fractures and alcohol misuse.

A standard definition of stroke unit was used; an area within a hospital where stroke patients are managed by a coordinated multidisciplinary team specialising in stroke management.1 2 The multidisciplinary team would meet at least once per week to plan patient care. Our broad definition of stroke unit did not discriminate between those providing acute care only, rehabilitation care only or a combination of the two (comprehensive unit). However, the majority of units studied (17/19) were comprehensive or rehabilitation units. We identified the development of stroke unit care at two levels: (a) the time when a hospital had any form of stroke unit service and (b) the time when a hospital had a stroke unit service that had the capacity to manage at least 50% of its stroke patient admissions. The existence and capacity of stroke units was identified through a range of approaches, including:

  1. Audits of stroke services carried out at intervals over the last 15 years.7

  2. Informal surveys carried out over the last 15 years to inform healthcare policy.5

  3. A national survey and quality assurance inspection of stroke services.8

  4. The National Scottish Stroke Care Audit; operating during the last 9 years.9

  5. Personal contact through a national network of stroke clinicians (Scottish Stroke Collaboration).

A number of approaches were taken in the analysis of outcomes. Firstly, we analysed the basic descriptive statistics of the number of stroke patients admitted to hospital over a 20 year period, the number of hospitals which had a stroke unit service and hence the number of stroke patients admitted to a hospital that could provide such a service. Secondly, we analysed 6 month case fatality and discharge destination outcomes, comparing hospitals with and without a stroke unit, and stratifying the analysis by the period of time (1986–1990, 1991–1995, 1996–2000 and 2001–2005). We compared outcomes in (a) a hospital without a stroke unit compared with one with a stroke unit and (b) a hospital with a ‘functional’ stroke unit that could manage at least 50% of its stroke patient population versus one which could not manage 50% of its stroke patients. These analyses looked at crude outcomes plus the OR for outcomes in a hospital with a stroke unit service. The ORs were calculated both for crude data and those adjusted for age, sex, socioeconomic deprivation (defined using the Carstairs–Morris index of deprivation) and comorbidity. In addition, the absolute risk reduction (ARR) was calculated using ORs and case fatality (CF) without stroke unit care as follows10:


The same approach was used for discharge outcome where the CF variable was the proportion discharged home from hospitals without stroke unit care.


Study population

From 1 January 1986 to 31 December 2005 there were 157 639 incident strokes recorded in Scotland and 55% were in women. Median age was 74 years (IQR 65–82). It can be seen from table 1 that the distribution of age and sex were invariant over time and the socioeconomic gradient was less pronounced towards the end of the study period. The prevalence of most comorbidities increased over time.

Table 1

Demographics of incident strokes 1986–1990

Figure 1 shows the 6 month case fatality over the 20 year period. Also shown is the proportion of hospitals with a stroke unit service of any kind or a ‘functional’ service able to provide for at least 50% of stroke patient admissions. There was a steady fall in case fatality over the study period. From the mid-1990s, there was a rapid rise in the proportion of hospitals with stroke unit services.

Figure 1

Six month case fatality, percentage of hospitals with any stroke unit and percentage of hospitals with stroke unit able to provide for at least 50% of stroke patients, plotted against study year. Solid line (triangle), 6 month case fatality; broken line (triangle), percentage of hospitals with stroke unit providing for 50%; broken line (circle), percentage of hospitals with stroke unit.

Table 2 shows the demographics of stroke patients treated in a hospital where there was a stroke unit compared with stroke patients treated in a hospital with no stroke unit. Patients treated in a hospital with a stroke unit were younger on average, had a higher percentage of people from the most deprived socioeconomic deprivation fifth and had a higher prevalence of comorbidities, especially atrial fibrillation, essential hypertension, coronary heart disease and alcohol misuse.

Table 2

Demographics of incident strokes by whether or not there was a stroke unit in the hospital

Table 3A shows the 6 month case fatality in hospitals with and without a stroke unit and when comparing a hospital with a stroke service able to provide for 50% of patients versus hospitals without such a service. Crude case fatality rates in hospitals with a stroke unit were consistently lower than in hospitals without a stroke unit.

Table 3

Crude outcomes (with 95% CI) by stroke unit status and study period: (A) 6 month case fatality and (B) proportion (%) discharged home

Table 3B shows the same analysis for discharge home which was consistently higher in hospitals with a stroke unit.

Table 4A shows the adjusted and unadjusted ORs for 6 month case fatality in hospitals, with and without a stroke unit, stratified by study period. Also shown is the comparison of hospitals able to provide stroke unit care for at least 50% of their stroke patients versus those that could not. The apparent odds reduction for death in patients admitted to a hospital with a stroke unit was consistently 17–23% compared with hospitals without a stroke unit. The apparent odds reduction for death (22%–38%) was more marked when using this stricter definition of a ‘functional’ stroke unit service that could take at least 50% of stroke patients. In both examples, the odds reductions for death were attenuated but not abolished after casemix adjustment.

Table 4

Crude and adjusted ORs (stroke unit in hospital versus s no stroke unit in hospital): (A) 6 month case fatality and (B) proportion (%) discharged home

Table 4B shows the same analysis for the outcome discharge home. There was an increase in the odds of discharge home associated with stroke unit hospitals. This increase was 17–23% after casemix adjustment.

Table 5A estimated the impact of a stroke unit policy on 6 month case fatality using three different approaches: (a) the crude data observed in this analysis (estimated 2440 additional survivors); (b) an estimate calculated using the adjusted ORs (table 4) from this analysis (estimated 1420 additional survivors); and (c) an estimate calculated from the 3% ARR seen in randomised trials (estimated 1425 additional survivors). The increasing access to stroke units in Scotland was associated with a substantial increase in survivors. During the period of stroke unit development (1991–2005), 6 month case fatality fell from 41% to 29% (ie, ARR of 12%). The estimate that is stratified by time period and adjusted for casemix suggests that an ARR of 2-4% may be attributed to the impact of stroke unit care. In the final study period (2001–2005) when stroke units were most prevalent, stroke unit care appeared to account for almost 200 extra survivors per year.

Table 5

Calculated impact of stroke unit care in Scotland, 1986–2005

Table 5B shows the same analysis but using discharge home as the variable in place of case fatality. During the period of stroke unit development (1991–2005), the proportion discharged home increased from 43% to 61% (ie, an absolute increase of 18%) of which 4–6% might be attributed to the impact of stroke unit care. In the final study period (2001–2005), an extra 470 discharges per year could be attributed to stroke unit care.


Stroke case fatality recorded using routine data has fallen substantially during this 20 year national study. It is apparent from this analysis that the development of stroke units could partly explain the fall in case fatality in hospitalised stroke patients. The remaining component may be explained by artefact (more stroke patients admitted to hospital with milder symptoms),11 12 changes in the natural history of stroke (eg, less severe stroke events)11 12 and improvements in general medical care.12

We believe this is the first long term study to have shown such an association in a whole population. The potential impact when based on unadjusted data is even larger than would have been estimated from randomised trials of stroke unit care. However, unadjusted estimates may be confounded by variations in casemix such as patient age and stroke severity. The estimate based on analyses adjusted for casemix (1420 extra survivors and 2351 extra discharges home) was very similar to that obtained using the absolute risk reductions from meta-analysis of clinical trials. Although no single method of estimating impact is ideal, it is reassuring to obtain similar estimates from different approaches.

The main strengths of our study are that we have studied a whole population of 5.1 million people over a 20 year period with complete follow-up to 1 year post stroke. Secondly, we used a definition of stroke unit status that has a standard definition and was externally validated.5 7–9 The basic definition2 was of multidisciplinary stroke unit care and the majority were comprehensive (acute and rehabilitation) or rehabilitation stroke units.5 Finally, our focus on whole hospital services minimises the risk of bias in patient selection for admission to a stroke unit since most hospitals served all patients within a geographical area. Alternative explanations of our observations (eg, hospitals with better case fatality results were more likely to establish stroke units) do not seem plausible.

The mechanisms by which stroke units improve survival have been subject to some study. In randomised trials, the survival benefit occurs largely at 1–4 weeks post stroke,13 is more marked in severe stroke patients13 and is linked to a reduction in complications, particularly those caused by immobility.14 The scale of benefit observed in our study is compatible with these observations. Furthermore, the size of association is also similar to that seen in a recent population based observational study from Sweden (adjusted hazard ratio (stroke unit versus no stroke unit) for death 0.79 in men and 0.83 in women).15 Our results cannot be explained by hyperacute interventions such as thrombolysis which were not in routine use during the period of study, would not be expected to reduce case fatality16 and would have a modest impact at a population level.17

There are some limitations to our study. Firstly, we used hospital discharge data and we therefore cannot always be certain of the precision of the diagnoses. However, an audit carried out by Information Services Division suggested that SMR identified stroke with an accuracy of 95% when a stroke code was recorded in the first diagnostic position.18 Secondly, although we included the key variables of age, sex, deprivation and comorbidity, our risk adjustments are not complete because of lack of clinical detail on items such as stroke severity. Finally, we were not able to directly study non-fatal outcomes such as disability. However, data from randomised trials1 indicate that the benefits in survival are mirrored by improvements in functional recovery and that discharge home is a reasonable proxy for functional recovery.


Stroke case fatality in Scotland has fallen steadily and substantially over two decades and has been mirrored by a rise in discharges home. Part of this improvement in prognosis can be explained by the policy of implementing a basic model of multidisciplinary stroke unit care.


We are grateful to all of the stroke clinicians who provided information about stroke services in Scotland.


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  • Funding This study was funded by the Chief Scientist Office (CSO), grant No CZH/4/389.

  • Competing interests None.

  • Ethics approval This study was conducted with the approval of the local university ethics committee.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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