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Association between restless legs syndrome and migraine
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    Endogenous morphine production may be impaired in both migraine and restless legs syndrome

    I read the article on association of restless legs and migraine headache by Chen with interest (1).

    Probably the two conditions share basic neuronal abnormalities such as neurotransmitter dysfunction.

    Opiates are an effective treatment for restless legs and also for the pain of migraine headaches.

    Morphine has been found to be produced endogenously in the nervous system (2) and is also a neu...

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    Conflict of Interest:
    None declared.