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Brain microbleeds as a potential risk factor for antiplatelet-related intracerebral haemorrhage
  1. Didier Leys,
  2. Charlotte Cordonnier
  1. Stroke Department, Université Lille Nord de France, Lille, France
  1. Correspondence to Professor Didier Leys, Université Lille Nord de France (Faculté de médecine Henri-Warembourg), EA 2691 59045 Lille, France; didier.leys{at}

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Brain microbleeds (BMBs) are markers of a bleeding-prone state and are associated with hypertensive small-vessel arteriopathies, and cerebral amyloid angiopathies (CAA).1 They are present in 5% of healthy adults, one-third of patients with ischaemic stroke, one-half of patients with first-ever intracerebral haemorrhage (ICH) and 80% of patients with recurrent ICH.2 In the paper by Gregoire et al (see page 679),3 BMBs were more frequent in antiplatelet users with ICH than in matched antiplatelet users without ICH and ICH patients not under antiplatelet agents. They were more numerous in antiplatelet users with ICH compared with controls, with an odds ratio of 1.33 per additional BMB (only adjusted with leucoaraiosis). This study has two limitations: the small sample size, and probably exclusion of the most severe cases, because of the high case death …

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