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Funding University of Lille.
Competing interests DL has had consultancy roles for and has contributed to advisory boards, steering committees, and adjudication committees for Sanofi–Aventis, Servier, Boehringer Ingelheim, AstraZeneca and Novo Nordisk, fees for which were paid towards research at ADRINORD (Association pour le Développement de la Recherche et de l'Innovation dans le Nord-Pas de Calais) or the research account of the hospital (délégation à la recherche du CHU de Lille). He was reimbursed for travel or accommodation expenses needed for the participation on these boards and committees. CC has participated in the BOREALIS trial (Sanofi–Aventis), fees for which were paid towards research at ADRINORD (Association pour le Développement de la Recherche et de l'Innovation dans le Nord-Pas de Calais). She was reimbursed for travel or accommodation and expenses needed for investigator meetings.
Provenance and peer review Commissioned; not externally peer reviewed.