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Longitudinal lesion of the spinal cord in a patient with Vogt–Koyanagi–Harada disease
  1. Yi Tang,
  2. Xiangbo Wang,
  3. Yan Ding,
  4. Cunjiang Li,
  5. Jianping Jia
  1. Department of Neurology, Xuanwu Hospital, Capital University of Medical Sciences, Beijing Neurology Consultation Center, Beijing, PR China
  1. Correspondence to Professor Xiangbo Wang, Department of Neurology, Xuanwu Hospital, Capital University of Medical Sciences, Beijing Neurology Consultation Center, 45 Changchun Street, Beijing 100053, PR China; xb90956{at}yahoo.com.cn

https://doi.org/10.1136/jnnp.2009.184432

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    Vogt–Koyanagi–Harada (VKH) disease, also known as uveomeningoencephalitis, is a granulomatous inflammatory disorder characterised by bilateral, chronic, diffuse panuveitis frequently associated with neurologic, auditory and integumentary manifestations. Neurological findings, including headache, vertigo and cranial palsies, have been attributed to the aseptic meningitis-like syndrome.1 Though brain parenchymal lesions have been reported in VKH disease, focal neurological signs that indicate a spinal cord lesion are extremely rare.2 Here, we present a case of a 16-year-old girl with VKH disease who presented with weakness of lower limbs and dysuria. MRI studies revealed a longitudinal lesion in the spinal cord. These constitute the first reported case of a VKH patient with an isolated spinal cord lesion.

    Case report

    A 16-year-old Chinese girl with VKH disease presented to the Beijing Neurology Consultation Center because of weakness of lower extremities and dysuria for 6 months. Two and a half years ago, she was diagnosed as having incomplete VKH disease in the largest ophthalmology centre in China, based on bilateral non-traumatic granulomatous iridocyclitis, retinal oedema and exudates, tinnitus and hearing loss.3 She was treated with oral prednisone (45 mg/day), and her visual impairment improved significantly. Six …

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    Footnotes

    • Funding This work was supported by the grants from the National Science Foundation of China (No 30900478) and Beijing Natural Science Foundation (No. 7102072).

    • Competing interests None.

    • Patient consent Obtained.

    • Provenance and peer review Not commissioned; externally peer reviewed.