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Neurophysiology of Alzheimer's disease: towards understanding the relationship between the EEG phenotype and onset of Alzheimer's disease
  1. Tânia Correa de Toledo Ferraz Alves
  1. Correspondence to Dr T Alves, R Ovídio de Campos s/n, HC-FMUSP-Centro de Medicina Nuclear 2a (LIM21), CEP 05403-010-SP, Brazil; tania_alves{at}

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Converging evidence from epidemiological studies suggest that the pathophysiological process of Alzheimer's disease (AD) begins years, if not decades, prior to the diagnosis of clinical dementia. In this regard, the paper written by Waal et al in this issue (see page 67) represents an advance in our understanding of the relationship between AD genetic risk (as represented by the APOE ε4 allele) and EEG phenotype.1

The presence of the APOE4 allele is a well known risk factor for …

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  • Competing interests None.

  • Provenance and peer review Commissioned; not externally peer reviewed.

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