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Cerebral amyloid angiopathy related inflammation: three case reports and a review
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  • Published on:
    Re:Anti-A? autoantibodies in cerebral amyloid angiopathy related inflammation: a role for pathogenesis?
    • P. Alan Barber, Professor of Clinical Neurology
    • Other Contributors:
      • Kong Khi Chung, Neil E. Anderson, David Hutchinson, Beth Synek

    We thank Drs DiFrancesco et al for their comments on our recent paper in which we proposed diagnostic criteria for cerebral amyloid related inflammation (CAA-I). The report by this group of an increase in anti- amyloid beta autoantibodies in a 68 year old man with probable CAA-I is of interest and may well help further our understanding of the pathogenesis of CAA-I. However, we agree that this finding must be confirmed in a...

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    Conflict of Interest:
    None declared.
  • Published on:
    Anti-A? autoantibodies in cerebral amyloid angiopathy related inflammation: a role for pathogenesis?
    • Jacopo C. DiFrancesco, MD, PhD
    • Other Contributors:
      • Fabrizio Piazza,2 Elisa Conti,2 Lucio Tremolizzo,1,2 Mario Savoiardo,3 Carlo Ferrarese1,2
    In their recent paper Chung and colleagues[1] describe 3 cases of cerebral amyloid angiopathy related inflammation (CAA-I) all confirmed by brain biopsy and review the scientific literature, proposing the criteria for probable and definite diagnosis. CAA-I is a rare and treatable encephalopathy affecting a subgroup of CAA patients, in which a predisposing condition is represented by the APOE ?4/?4 genotype in the majority of pati...
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    Conflict of Interest:
    None declared.