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Frequencies of LRRK2 variants in Thai patients with Parkinson's disease: evidence for an R1628P founder
  1. Teeratorn Pulkes1,
  2. Chutima Papsing1,
  3. Surakameth Mahasirimongkol2,
  4. Manisa Busabaratana1,
  5. Kongkiat Kulkantrakorn3,
  6. Somsak Tiamkao4
  1. 1Division of Neurology, Department of Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand
  2. 2Medical Genetic Section, National Institute of Health, Department of Medical Sciences, Ministry of Public Health, Nonthaburi, Thailand
  3. 3Division of Neurology, Department of Medicine, Faculty of Medicine, Thammasat University, Pathumthani, Thailand
  4. 4Division of Neurology, Department of Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand
  1. Correspondence to Dr T Pulkes, Division of Neurology, Department of Medicine, Ramathibodi Hospital, Mahidol University, 270 Rama 6 Road, Bangkok 10400, Thailand; ratpk{at}mahidol.ac.th

https://doi.org/10.1136/jnnp.2009.194597

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    Mutations in the leucine rich repeat kinase 2 (LRRK2) gene are associated with familial and idiopathic Parkinson's disease (PD). The occurrence of common LRRK2 mutations is different among differing ethnic groups. The LRRK2 G2385R (c.7153G>R) and R1628P (c.4883G>C) mutations have been shown to be common risk factors for PD in East Asian populations while G2019S (c.6050G>A) is common in Europeans.1 2 Thailand is located in Southeast Asia, geographically close to China. Major Asian diasporas into mainland East Asia have taken place since the prehistoric period until mass Chinese emigration during the Chinese civil war and World War II.3 Thus it is likely that the Chinese and Thai populations may share some regional characteristic genotypes, including LRRK2 variants. These data led us to analyse the frequencies of the common LRRK2 R1628P, G2385R and G2019S mutations in our cohort of idiopathic PD patients.

    We recruited 154 Thai patients with sporadic PD (males=56.5%, mean age of onset=61.2±9.8 years) and 156 control subjects over 65 years of age without any clinical features of parkinsonism. The research protocol was approved by the ethic committees from all participating hospitals. All patients provided informed consent.

    The majority of the Thai population comprises indigenous Thai people and Chinese immigrants. To classify the ethnic groups of the population, we divided the cases into three groups: (1) Thai; (2) …

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    Footnotes

    • Funding This study was supported by the Thailand Research Fund and the Neurogenetics Fund (3001180) of Ramathibodi Hospital Foundation.

    • Competing interests None.

    • Ethics approval This study was conducted with the approval of the ethics committees from all participating hospitals (Ramathibodi Hospital, Mahidol University, Thammasat University and Khon Kaen University).

    • Provenance and peer review Not commissioned; externally peer reviewed.