Statistics from Altmetric.com
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.
- EMG (single fibre)
- HMSN (charcot-marie-tooth)
- lambert eaton syndrome
- motor neuron disease
- molecular biology
Although amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease diffusely affecting the human motor system, there is a large variability in the clinical expression of the disease (site of onset, speed of progression, involvement of lower- or upper-motor neuron). The phenotypes, particularly at the site of onset, are highly heterogeneous. Bulbar muscles are first affected in some patients, and upper- or lower-limb muscles are initially involved in others; the manifestations are focal and discrete at clinical onset and then progress contiguously outward over time to become diffuse and complex.1 2
In other common neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease, the molecular pathogenesis is characterised by the misfolding of proteins that assemble into ordered aggregates in affected neurons. So far, it has been considered that the diseases affect the most vulnerable neurons to form aggregates and that non-cell …
Linked article 300141
Competing interests None.
Provenance and peer review Commissioned; internally peer reviewed.