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Neurodegenerative disease
Onset and spreading patterns of lower motor neuron involvements predict survival in sporadic amyotrophic lateral sclerosis
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    Focal onset of ALS

    Focal onset of ALS is attractive; it superficially mirrors what is encountered clinically, initial weakness in an arm, leg or bulbar muscles and is an explanation for phenotypic variation in terms of site of onset and rate of progression (Ravits and La Spada 2009). I congratulate Fujimura-Kimono and colleagues in their efforts to define patterns of spread through the ALS motor system and finding that the interval between...

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    Conflict of Interest:
    None declared.