Article Text

Download PDFPDF

MRI-guided STN DBS in Parkinson's disease without microelectrode recording: efficacy and safety
  1. T Foltynie1,
  2. L Zrinzo1,2,
  3. I Martinez-Torres3,
  4. E Tripoliti1,
  5. E Petersen4,
  6. E Holl1,5,
  7. I Aviles-Olmos1,
  8. M Jahanshahi1,
  9. M Hariz1,6,
  10. P Limousin1
  1. 1Unit of Functional Neurosurgery, Sobell Department of Motor Neuroscience, UCL Institute of Neurology, Queen Square, London, UK
  2. 2Victor Horsley Department of Neurosurgery, National Hospital for Neurology and Neurosurgery, Queen Square, London, UK
  3. 3Department of Neurology, Hospital La Fe, Valencia, Spain
  4. 4Department of Neurosurgery, University of Texas, Southwestern, Dallas, Texas, USA
  5. 5Department of Neurosurgery, Medical University, Graz, Austria
  6. 6Department of Neurosurgery, University Hospital, Umea, Sweden
  1. Correspondence to Thomas Foltynie, Unit of Functional Neurosurgery, Sobell Department of Motor Neuroscience, Box 146, National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG, UK; t.foltynie{at}


Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is a commonly employed therapeutic procedure for patients with Parkinson's disease uncontrolled by medical therapies. This series describes the outcomes of 79 consecutive patients that underwent bilateral STN DBS at the National Hospital for Neurology and Neurosurgery between November 2002 and November 2008 using an MRI-guided surgical technique without microelectrode recording. Patients underwent immediate postoperative stereotactic MR imaging. The mean (SD) error in electrode placement was 1.3 (0.6) mm. There were no haemorrhagic complications. At a median follow-up period of 12 months, there was a mean improvement in the off-medication motor part of the Unified Parkinson's Disease Rating Scale (UPDRS III) of 27.7 points (SD 13.8) equivalent to a mean improvement of 52% (p<0.0001). In addition, there were significant improvements in dyskinesia duration, disability and pain, with a mean reduction in on-medication dyskinesia severity (sum of dyskinesia duration, disability and pain from UPDRS IV) from 3.15 (SD 2.33) pre-operatively, to 1.56 (SD 1.92) post-operatively (p=0.0001). Quality of life improved by a mean of 5.5 points (median 7.9 points, SD 17.3) on the Parkinson's disease Questionnaire 39 summary index. This series confirms that image-guided STN DBS without microelectrode recording can lead to substantial improvements in motor disability of well-selected PD patients with accompanying improvements in quality of life and most importantly, with very low morbidity.

  • Parkinson's disease
  • stereotaxic surgery

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.


  • See Editorial Commentary, p 356

  • Funding Other Funders: Parkinson's Appeal.

  • Competing interests The authors have no competing interests in the publication of this article.

  • Provenance and peer review Not commissioned; externally peer reviewed.

Linked Articles