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Fasciculation-cramp syndrome preceding anterior horn cell disease: an intermediate syndrome?

Abstract

Cramp-fasciculation syndrome (cramp-FS) is an ill-defined condition with uncertain clinical limits. The authors studied a 55-year-old man with progressively more severe, widespread fasciculations and cramps during a 6-year-period. Mild progressive lower motor neuron loss, shown by motor unit number and multi-motor unit potential (MUP) analysis, developed during the 4 years after onset, which stabilised during a further 2-year follow-up. Cramp-FS is generally a benign syndrome, probably with several causations. Our patient developed a limited form of anterior horn cell degeneration perhaps representing a syndrome transitional with amyotrophic lateral sclerosis. Cramp-FS merits more detailed study.

  • After-discharges
  • amyotrophic lateral sclerosis
  • cramp-fasciculation syndrome
  • fasciculations
  • myokymia
  • EMG
  • motor neuron disease
  • ALS

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