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Rapidly progressive atypical parkinsonism associated with frontotemporal lobar degeneration and motor neuron disease
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    Ataxin-2 needs to be considered in TDP-43 positive patients with PSP-like parkinsonism and motor neuron disease


    Espay and colleagues report a detailed clinical and pathological study of two unrelated individuals with rapidly progressive atypical parkinsonism (similar to progressive supranuclear palsy, PSP), and additional frontotemporal and motor neuron involvement, in whom TDP-43 inclusion pathology was demonstrated. (1) Sequencing of PGRN and TARDBP gene coding regions was negative, and therefore no genetic cause...

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    Conflict of Interest:
    None declared.