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Influence of prior transient ischaemic attack on stroke prognosis
  1. Corine Aboa-Eboulé1,2,
  2. Yannick Béjot2,
  3. Guy-Victor Osseby2,
  4. Olivier Rouaud2,
  5. Christine Binquet1,
  6. Christine Marie3,
  7. Yves Cottin4,
  8. Maurice Giroud2,
  9. Claire Bonithon-Kopp1
  1. 1National Institute for Health and Medical Research (INSERM) CIE 01, Centre d'investigation clinique/épidémiologie clinique du CHU de Dijon, Faculté de Médecine, Dijon, France
  2. 2Dijon Stroke Registry, EA 4184, Department of Neurology, University Hospital and Faculty of Medicine, Dijon, France
  3. 3Laboratory of Pharmacodynamics, U887 Motricity-Plasticity, University of Burgundy, Burgundy, France
  4. 4Department of Cardiology and observatoire des Infarctus de Côte-d'Or (RICO), LPPCE, IFR Santé-STIC, University of Burgundy, University Hospital and Faculty of Medicine, France
  1. Correspondence to Dr Yannick Béjot, Dijon Stroke Registry, Department of Neurology, University Hospital, 3 Rue du Faubourg Raines, 21000 Dijon, France; ybejot{at}


Background To evaluate potential neuroprotection afforded by prior transient ischaemic attack (TIA) on functional and survival outcomes after ischaemic stroke.

Methods All cases of first-ever ischaemic strokes, diagnosed between 1985 and 2008, were identified from the Dijon Stroke Registry. Patients were analysed in three groups according to the time interval between prior TIA and stroke (<4 weeks, ≥4 weeks, no TIA) or the duration of TIA (≤30 min, >30 min, no TIA). Outcomes were severe functional handicap (unable to walk, bedridden or death) at hospital discharge or at outpatient consultation, and 1-month and 1-year any-cause mortality. Stratified analyses were performed by stroke subtypes (non-lacunar, lacunar). Generalised linear mixed models and Cox proportional hazard models with a sandwich covariance matrix accounting for the treatment centre as a random effect were used for multivariate analyses.

Results Among the 3015 patients with first-ever ischaemic stroke, 389 had had a prestroke TIA <4 weeks and 97 a prestroke TIA ≥4 weeks. Patients with TIAs had better ambulatory status (adjusted OR 0.61, 95% CI 0.45 to 0.81; p=0.008) and better survival at 1 month (adjusted HR 0.76, 95% CI 0.65 to 0.89; p=0.0006) and at 1 year (adjusted HR 0.72, 95% CI 0.67 to 0.76; p<0.0001) than those with no TIAs. Prestroke TIA <4 weeks and TIA duration ≤30 min also significantly improved the outcomes in overall, non-lacunar and lacunar strokes.

Conclusions Recent prestroke TIA was associated with better functional outcome and lower 1-month and 1-year mortality after stroke, suggesting a neuroprotective effect.

  • Transient ischaemic attack
  • cerebral infarction
  • prognosis
  • stroke
  • registries
  • epidemiology

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  • Funding The Dijon Stroke Registry was supported by grants from National Institute for Health and Medical Research (INSERM) and Institute for Public Health Surveillance (InVS).

  • Competing interests None.

  • Provenance and peer review Not commissioned; externally peer reviewed.