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Lupus anticoagulant in patients with subarachnoid haemorrhage
  1. Francis A T M van Lier1,
  2. Rolf T Urbanus2,
  3. Nicolien K de Rooij1,
  4. Gabriel J E Rinkel1,
  5. Catherina C J Frijns1
  1. 1Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Centre Utrecht, Utrecht, The Netherlands
  2. 2Department of Clinical Chemistry and Haematology, University Medical Centre Utrecht, Utrecht, The Netherlands
  1. Correspondence to Dr C J M Frijns, Department of Neurology, C03.229, University Medical Centre Utrecht, PO Box 85500, 3584 Utrecht, The Netherlands; c.j.m.frijns{at}


Background In aneurysmal subarachnoid haemorrhage (SAH), delayed cerebral ischaemia (DCI) is a serious complication that occurs in approximately 30% of patients. Lupus anticoagulant (LAC) is a risk factor for thrombotic events and has been associated with cerebral infarction after SAH.

Objective To determine the frequency of LAC in patients with SAH and its association with DCI.

Methods Patients with aneurysmal SAH from a prospectively collected database between 1998 and 2009 were included. Presence of LAC was detected with dilute Russell's viper venom time reagents. Investigation of the association with DCI was planned in case of an increased prevalence of LAC compared with the general population.

Results Of 511 patients, LAC was detected in only six (1.2%; 95% CI 0.4 to 2.5%). In two of these six patients, DCI was diagnosed.

Conclusion No evidence was found that LAC contributes to the development of DCI in patients with aneurysmal SAH.

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  • Competing interests None.

  • Ethics approval This study was conducted with the approval of the ethics committee of the University Medical Centre Utrecht, The Netherlands.

  • Provenance and peer review Not commissioned; externally peer reviewed.