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- Lewy body
- frontal lobe
- cognitive neuropsych
- Alzheimer's disease
- clinical neurology
- molecular biology
Hexanucleotide repeat expansions in the C9ORF72 gene are an important cause of frontotemporal dementia (FTD) and amyotrophic lateral sclerosis.1 ,2 Whether they have a role in other conditions remains unclear.3 ,4 We previously identified in FTD a strong association between repeat expansions in C9ORF72 and the presence of psychosis.4 This raises the question whether C9ORF72 expansions might also have a role in dementia with Lewy bodies (DLB), in which hallucinations and delusions are prevalent. The study addressed this question.
The cohort comprised 102 consecutive patients who fulfilled criteria for ‘probable DLB’, exhibiting at least two of the cardinal features: fluctuating …
Funding The work was supported by the Medical Research Council (MRC G0701441), the Bill Edmonds bequest and the Manchester Neurological Research Trust.
Competing interests None.
Ethics approval Ethics approval was provided by Oldham Local Research Ethics Committee.
Provenance and peer review Not commissioned; externally peer reviewed.