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Psychosis, C9ORF72 and dementia with Lewy bodies
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- Published on: 13 April 2016
- Published on: 13 April 2016C9ORF72 in dementia with Lewy bodiesShow More
INTRODUCTION Recent studies have shown that a large hexanucleotide expansion in C9ORF72 is the most common cause of inherited Frontotemporal Lobar Degeneration (FTLD) and Motor Neurone Disease (MND).1 In pathological terms, expansion carriers show a distinctive molecular signature within the dentate gyrus granule cells and CA4 pyramidal cells of the hippocampus and granule cells of the cerebellum characterised by TDP-43-ne...
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