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Cerebral metabolic rate for glucose of NPH patients increases in shunt-reponders
  1. A Mangiola1,
  2. M L Calcagni2,
  3. P De Bonis1,
  4. L Rigante1,
  5. A Pompucci1,
  6. M D La Valle2,
  7. L Indovina2,
  8. A Giordano2,
  9. C Anile1
  1. 1Department of Neurosurgery, Catholic University School of Medicine, Rome, Italy
  2. 2Department of Nuclear Medicine, Catholic University School of Medicine, Rome, Italy
  1. Correspondence to Dr Pasquale De Bonis, Institute of Neurosurgery, Catholic University School of Medicine, L go F. Vito, 1, Rome 00168, Italy; debonisvox{at}

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Normal pressure hydrocephalus (NPH) is a potentially treatable form of dementia characterised by a triad of symptoms (dementia, gait disturbance and urinary incontinence).

This triad is not pathognomic and may also be seen in other degenerative brain diseases (DBD). Diagnosis of NPH is based upon the clinical history/physical examination, brain imaging and CSF dynamics evaluation.1 The regional cerebral metabolic rate for glucose (rCMRglu) has been extensively measured in DBD. However, few PET studies describe a heterogeneous pattern of metabolic alterations in NPH and there is no conclusive evidence at present of an increase in metabolism after insertion of a CSF shunt.2 3

This is a preliminary study reporting changes in PET rCMRglu in patients with …

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  • Competing interests None.

  • Ethics approval The Ethics Committee of the Catholic University of Rome approved this study.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Data sharing statement Raw data are available and have been included in table 1, and online supplementary tables 2 and 3.