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Prospective outcome of rapid eye movement sleep behaviour disorder: psychiatric disorders as a potential early marker of Parkinson's disease
  1. Yun Kwok Wing1,
  2. Shirley Xin Li1,
  3. Vincent Mok2,
  4. Siu Ping Lam1,
  5. Joshua Tsoh1,
  6. Anne Chan2,
  7. Mandy Wai Man Yu1,
  8. Christine Y K Lau2,
  9. Jihui Zhang1,
  10. Crover Kwok Wah Ho1
  1. 1Department of Psychiatry, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China
  2. 2Department of Medicine and Therapeutics, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China
  1. Correspondence to Dr Yun-Kwok Wing, Professor, Director of Sleep Assessment Unit, Department of Psychiatry, Shatin hospital, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China; ykwing{at}

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Increasing evidence suggests that rapid eye movement sleep behaviour disorder (RBD) is a heralding feature associated with evolving α-synucleinopathy-related neurodegenerative disorders.1–4 Several neurobiological markers such as olfactory abnormality were associated with the development of neurodegenerative disorders in ‘idiopathic’ RBD (iRBD) patients.5 On the other hand, pre-morbid psychiatric disorders were suggested as an important but often neglected preclinical marker of Parkinson's disease (PD),6 and its role is unclear in iRBD patients. The current study aimed to provide a quantitative risk estimate of neurodegenerative outcome, and to investigate the role of psychiatric disorders in predicting future neurodegenerative disorders in a prospective cohort of Hong Kong Chinese iRBD patients.

Ninety-one iRBD patients (82.4% men) (recruited during 1994–2009) were prospectively followed-up with routine clinical assessments in our sleep centre for a mean duration of 5.6 years (SD 3.3).1 An additional research-based follow-up protocol has been implemented since 2008, which included neuropsychiatric examinations as conducted by the research …

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  • Funding This work was supported by General Research Fund grant (CUHK 476610) of Research Grants Council, Hong Kong SAR, China.

  • Competing interests None.

  • Patient consent Obtained.

  • Ethics approval Ethics approval was provided by Joint CUHK-NTEC Clinical Research Ethics Committee.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Data sharing statement The corresponding author declares that all the authors have agreed to the condition regarding data sharing stated in the authorship agreement form.