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Funding This work was supported by General Research Fund grant (CUHK 476610) of Research Grants Council, Hong Kong SAR, China.
Competing interests None.
Patient consent Obtained.
Ethics approval Ethics approval was provided by Joint CUHK-NTEC Clinical Research Ethics Committee.
Provenance and peer review Not commissioned; externally peer reviewed.
Data sharing statement The corresponding author declares that all the authors have agreed to the condition regarding data sharing stated in the authorship agreement form.