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For neurologists, tracking down the cause of multiple sclerosis (MS) has echoes of the search for the elusive Higgs boson. At times close, at times far. Does vitamin D give us a 125 GeV signature? What evidence do we have, and what evidence do we need, for a central role of vitamin D in the pathogenesis of MS? If we divide the current information along traditional observational and interventional lines, then another track may have been visualised. Soilu-Hänninen1 and colleagues asked what would happen if vitamin D (20 000 IU vitamin D3 per week) was added to standard disease modifying …