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A MODERN PERSPECTIVE ON THE TOP 100 CITED JNNP PAPERS OF ALL TIME
Polyneuropathy in critically ill patients
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  1. C F Bolton
  1. Correspondence to Dr C F Bolton, Department of Medicine, 1040 Etherington Hall, 94 Stuart St., Kingston, ON, Canada, K7L3N6; cb41{at}queensu.ca

https://doi.org/10.1136/jnnp-2011-300997

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    Record: 77 of 100

    POLYNEUROPATHY IN CRITICALLY ILL PATIENTS1

    Authors: C F Bolton, J J Gilbert, A F Hahn, W J Sibbald

    Year published: 1984

    Number of times cited: 249

    A common cause of muscle weakness in the intensive care unit

    More than 30 years ago, during a 4-year period, we observed five patients who presented in the ICU with unexplained difficulty in weaning from mechanical ventilation, and with limb weakness. At that time weaning difficulties had been attributed to diaphragmatic fatigue, and limb weakness to a catabolic myopathy. Clinical signs indicated a motor and sensory polyneuropathy, and electrophysiological tests, a primary axonal degeneration of motor and sensory fibres. Autopsy studies of both the central and peripheral nervous systems in …

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