Background There is a growing body of evidence that inflammatory processes play a role in the development of neuropsychiatric symptoms in Huntington's disease (HD).

Aims To investigate the relationship between C-reactive protein (CRP) concentration in blood on the one hand and neuropsychiatric symptoms on the other hand in HD mutation carriers compared to non-mutation carriers, both cross-sectionally and longitudinally.

Methods In 2003, a longitudinal cohort study was initiated in Leiden, The Netherlands, comprising 154 mutation carriers and 56 non-carriers. In 2005–2007 and 2009–2011 a first and second wave of follow-up was conducted. Blood samples for the assessment of CRP were obtained during the first and second wave of follow-up, in addition to a battery of psychometric measures, cognitive functioning tests, and a neurological examination. Multivariate regression analyses to associate neuropsychiatric symptoms with CRP and analyses of (co)variance for comparisons between different stages of HD and controls will be used.

Results We will present the results regarding associations between CRP on the one hand and HD disease stage and several neuropsychiatric symptoms on the other hand, both cross-sectionally and longitudinally.