Brain atrophy and lesion load predict long term disability in multiple sclerosis

Veronica Popescu; Federica Agosta; Hanneke E Hulst; Ingrid C Sluimer; Dirk L Knol; Maria Pia Sormani; Christian Enzinger; Stefan Ropele; Julio Alonso; Jaume Sastre-Garriga; Alex Rovira; Xavier Montalban; Benedetta Bodini; Olga Ciccarelli; Zhaleh Khaleeli; Declan T Chard; Lucy Matthews; Jaqueline Palace; Antonio Giorgio; Nicola De Stefano; Philipp Eisele; Achim Gass; Chris H Polman; Bernard M J Uitdehaag; Maria Jose Messina; Giancarlo Comi; Massimo Filippi; Frederik Barkhof; Hugo Vrenken; on behalf of the MAGNIMS Study Group

doi:10.1136/jnnp-2012-304094

Article info

Multiple sclerosis

Research paper

Brain atrophy and lesion load predict long term disability in multiple sclerosis

Authors

Veronica Popescu Department of Radiology and Nuclear Medicine, VU University Medical Center, Amsterdam, The Netherlands PubMed articles Google scholar articles
Federica Agosta Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, Vita-Salute University and San Raffaele Scientific Institute, Milan, Italy PubMed articles Google scholar articles
Hanneke E Hulst Department of Radiology and Nuclear Medicine, VU University Medical Center, Amsterdam, The Netherlands Department of Anatomy and Neurosciences, VU University Medical Center, Amsterdam, The Netherlands PubMed articles Google scholar articles
Ingrid C Sluimer Department of Radiology and Nuclear Medicine, VU University Medical Center, Amsterdam, The Netherlands PubMed articles Google scholar articles
Dirk L Knol Department of Epidemiology and Biostatistics, VU University Medical Center, Amsterdam, The Netherlands PubMed articles Google scholar articles
Maria Pia Sormani Biostatistics Unit, Department of Health Sciences, University of Genoa, Genoa, Italy PubMed articles Google scholar articles
Christian Enzinger Department of Neurology, Medical University of Graz, Austria PubMed articles Google scholar articles
Stefan Ropele Department of Neurology, Medical University of Graz, Austria PubMed articles Google scholar articles
Julio Alonso Magnetic Resonance Unit, Department of Radiology, Vall d'Hebron University Hospital, Autonomous University of Barcelona, Barcelona, Spain PubMed articles Google scholar articles
Jaume Sastre-Garriga Neurology/Neuroimmunology Unit, MS Centre of Catalonia (Cemcat), Vall d’Hebron University Hospital, Barcelona, Spain PubMed articles Google scholar articles
Alex Rovira Neurology/Neuroimmunology Unit, MS Centre of Catalonia (Cemcat), Vall d’Hebron University Hospital, Barcelona, Spain PubMed articles Google scholar articles
Xavier Montalban Magnetic Resonance Unit, Department of Radiology, Vall d'Hebron University Hospital, Autonomous University of Barcelona, Barcelona, Spain PubMed articles Google scholar articles
Benedetta Bodini NMR Research Unit, University College London (UCL) Institute of Neurology, London, UK PubMed articles Google scholar articles
Olga Ciccarelli NMR Research Unit, University College London (UCL) Institute of Neurology, London, UK National Institute for Health Research (NIHR) University College London Hospitals (UCLH) Biomedical Research Centre, UK PubMed articles Google scholar articles
Zhaleh Khaleeli NMR Research Unit, University College London (UCL) Institute of Neurology, London, UK PubMed articles Google scholar articles
Declan T Chard NMR Research Unit, University College London (UCL) Institute of Neurology, London, UK National Institute for Health Research (NIHR) University College London Hospitals (UCLH) Biomedical Research Centre, UK PubMed articles Google scholar articles
Lucy Matthews Nuffield Department of Clinical Neurosciences, University of Oxford, UK PubMed articles Google scholar articles
Jaqueline Palace Centre for Functional Magnetic Resonance Imaging of the Brain, University of Oxford, UK PubMed articles Google scholar articles
Antonio Giorgio Department of Medicine, Surgery & Neuroscience, University of Siena, Siena, Italy PubMed articles Google scholar articles
Nicola De Stefano Department of Medicine, Surgery & Neuroscience, University of Siena, Siena, Italy PubMed articles Google scholar articles
Philipp Eisele Department of Neurology, UniversitätsMedizin Mannheim, University of Heidelberg, Germany PubMed articles Google scholar articles
Achim Gass Department of Neurology, UniversitätsMedizin Mannheim, University of Heidelberg, Germany Department of Neurology, University Hospital Basel, Switzerland PubMed articles Google scholar articles
Chris H Polman Department of Neurology, VU University Medical Center, Amsterdam, The Netherlands PubMed articles Google scholar articles
Bernard M J Uitdehaag Department of Epidemiology and Biostatistics, VU University Medical Center, Amsterdam, The Netherlands PubMed articles Google scholar articles
Maria Jose Messina Department of Neurology, Institute of Experimental Neurology, Vita-Salute University and San Raffaele Scientific Institute, Milan, Italy PubMed articles Google scholar articles
Giancarlo Comi Department of Neurology, Institute of Experimental Neurology, Vita-Salute University and San Raffaele Scientific Institute, Milan, Italy PubMed articles Google scholar articles
Massimo Filippi Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, Vita-Salute University and San Raffaele Scientific Institute, Milan, Italy Department of Neurology, Institute of Experimental Neurology, Vita-Salute University and San Raffaele Scientific Institute, Milan, Italy PubMed articles Google scholar articles
Frederik Barkhof Department of Radiology and Nuclear Medicine, VU University Medical Center, Amsterdam, The Netherlands PubMed articles Google scholar articles
Hugo Vrenken Department of Radiology and Nuclear Medicine, VU University Medical Center, Amsterdam, The Netherlands Department of Physics and Medical Technology, VU University Medical Center, Amsterdam, The Netherlands PubMed articles Google scholar articles
The members of MAGNIMS Study Group Steering Committee are A Rovira, N de Stefano, X Montalban, F Barkhof, C Enzinger, M Filippi, J Frederiksen, L Kappos, O Ciccarelli, J Palace, H Vrenken, MA Rocca, T Yousry Google scholar articles

Correspondence to Dr V Popescu, Department of Radiology, VU University Medical Centre, Room PK -1 X 108, De Boelelaan 1118, Amsterdam 1081 HZ, The Netherlands; v.popescu{at}vumc.nl

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Citation

Popescu V, Agosta F, Hulst HE, et al

Brain atrophy and lesion load predict long term disability in multiple sclerosis

Journal of Neurology, Neurosurgery & Psychiatry 2013;84:1082-1091.

Publication history

Received September 7, 2012
Revised February 26, 2013
Accepted February 27, 2013
First published March 23, 2013.

Online issue publication

September 02, 2013

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