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The first demyelinating event, often known as clinically isolated syndrome (CIS), represents the earliest stage of multiple sclerosis (MS). A better understanding of the role of environmental factors involved in CIS could provide insights into pathogenic mechanisms in MS and help identify biomarkers that predict progression to clinically definite MS. The paper by Weinstock-Guttman et al1 in this issue examines the associations between serum cholesterol and disease progression in CIS patients following the first demyelinating event.
The paper by Weinstock-Guttman et al1 investigates the possibility of an environmental factor nexus with serum lipid profile based on the premise that cholesterol and its metabolites have important functions in modulating immune responses and neuronal functions. …
Competing interests None.
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