Article Text

Download PDFPDF
Research paper
MRI and neurophysiology in vestibular paroxysmia: contradiction and correlation
  1. Christoph Best1,2,
  2. Joachim Gawehn3,
  3. Heidrun H Krämer4,
  4. Frank Thömke2,
  5. Tugba Ibis2,
  6. Wibke Müller-Forell3,
  7. Marianne Dieterich5,6,7
  1. 1Department of Neurology, Vestibular Research Unit, Philipps-University, Marburg, Germany
  2. 2Department of Neurology, Johannes Gutenberg-University, Mainz, Germany
  3. 3Department of Neuroradiology, University Medical Center, Johannes Gutenberg-University, Mainz, Germany
  4. 4Department of Neurology, Justus Liebig University, Giessen, Germany
  5. 5Department of Neurology, Ludwig-Maximilians-University, Munich, Germany
  6. 6Center for Vertigo and Balance Disorders—IFBLMU, Ludwig-Maximilians-University, Munich, Germany
  7. 7Munich Cluster for Systems Neurology (SyNergy), Ludwig-Maximilians-University, Munich, Germany
  1. Correspondence to Dr Christoph Best, Department of Neurology, Vestibular Research Unit, Philipps-University, Baldingerstrasse, Marburg 35043, Germany; bestc{at}


Background Vestibular paroxysmia (VP) is defined as neurovascular compression (NVC) syndrome of the eighth cranial nerve (N.VIII). The aim was to assess the sensitivity and specificity of MRI and the significance of audiovestibular testing in the diagnosis of VP.

Methods 20 VP patients and, for control, 20 subjects with trigeminal neuralgia (TN) were included and underwent MRI (constructive interference in steady-state, time-of-flight MR angiography) for detection of a NVC between N.VIII and vessels. All VP patients received detailed audiovestibular testing.

Results A NVC of N.VIII could be detected in all VP patients rendering a sensitivity of 100% and a specificity of 65% for the diagnosis of VP by MRI. Distance between brain stem and compressing vessels varied between 0.0 and 10.2 mm. In 15 cases, the compressing vessel was the anterior inferior cerebellar artery (75%, AICA), the posterior inferior cerebellar artery in one (5%, posterior inferior cerebellar artery (PICA)), a vein in two (10%) and the vertebral artery (10%, VA) in another two cases. Audiovestibular testing revealed normal results in five patients (25%), a clear unilateral loss of audiovestibular function in nine patients (45%) and audiovestibular results with coinstantaneous signs of reduced and increased function within the same nerve in six patients (30%). From the 20 TN patients 7, (35%) showed a NVC of the N.VIII (5 AICA, 1 PICA, 1 vein).

Conclusions Only the combination of clinical examination, neurophysiological and imaging techniques is capable of (1) defining the affected side of a NVC and to (2) differentiate between a deficit syndrome and increased excitability in VP.

  • MRI

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.