The neural basis of multidomain self-appraisal deficits in frontotemporal dementia

Loss of insight, defined as a lack of awareness of cognitive deficits or behavioural changes, is one of the most salient clinical features in frontotemporal dementia (FTD).1 A significant proportion of patients with Alzheimer's disease (AD) also display this phenomenon, and its neuroanatomical correlates have been the focus of recent research.2

In the first place, knowledge about insight in dementia is important for managing issues, as disturbed insight negatively influences adaptation behaviour. Moreover, studying insight can teach us a lot about brain–behaviour relationships. Self-appraisal is a metacognitive function specific to human beings, implicating the capacity to evaluate one's cognitive performance. It is closely related to the processes of selection, monitoring and …