Article Text

Download PDFPDF
Research paper
Interaction of age with the ischaemic penumbra, leptomeningeal collateral circulation and haemodynamic variables in acute stroke: a pilot study
  1. Smriti Agarwal1,
  2. Daniel J Scoffings2,
  3. P Simon Jones1,
  4. S Tulasi Marrapu1,
  5. Patrick J Barry4,
  6. Eoin W O'Brien4,
  7. Jean-Claude Baron1,3,
  8. Elizabeth A Warburton1,4
  1. 1Clinical Neurosciences, University of Cambridge, Cambridge, UK
  2. 2Department of Radiology, Addenbrooke's Hospital, Cambridge, UK
  3. 3INSERM UMR894, Sorbonne Paris Cité, Université Paris 5, France
  4. 4Stroke Unit, Addenbrooke's Hospital, Cambridge, UK
  1. Correspondence to Dr S Agarwal, Department of Clinical Neurosciences, Addenbrooke's Hospital, Box 83, Hills Road, Cambridge CB2 0QQ, UK; smriti.agarwal{at}


Background Increasing age is the single largest non-modifiable risk factor for ischaemic stroke. Animal models have substantiated the view that age related neuron vulnerability to ischaemia plays a role in stroke and other age related neurological diseases. Given the key role of the ischaemic penumbra in stroke pathophysiology, we hypothesised that age has an impact on penumbral tissue and its acute determinants.

Methods We studied a prospective cohort of patients (n=39) at a mean time of 154.7 min from stroke onset, using state of the art whole brain perfusion CT and CT angiography. Penumbral and core were defined using quantitative voxel based thresholds for mean transit time and cerebral blood volume (CBV). Collateral vessel scores were assessed and haemodynamic variables (ie, cerebral blood flow and CBV) were measured in affected and unaffected tissues.

Results While age correlated negatively with normalised penumbral volume (Kendall's τ b=−0.234, p=0.048) and lesion volume (Kendall's τ b=0.238, p=0.045), core volume remained unchanged, accompanied by an incremental collateral response with age (Kendall's τ b=0.496, p<0.0001). Haemodynamic variables remained unaffected by age in our cohort.

Conclusions These findings, described for the first time in a clinical cohort using whole brain CT perfusion and concomitant vascular imaging, suggest that age has a differential effect on acute tissue compartments in the wake of a preserved collateral vascular response and haemodynamic parameters. In agreement with the preclinical literature, the results point to a distinct tissue response to acute ischaemia in the ageing brain and merit validation studies in larger cohorts, particularly in relation to clinical outcomes.

  • Stroke
  • Cerebral Blood Flow
  • Cerebrovascular Disease

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

Linked Articles