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Long-term prognosis of aphasia after stroke
  1. Hanane El Hachioui1,
  2. Hester F Lingsma2,
  3. Mieke W M E van de Sandt-Koenderman3,4,
  4. Diederik W J Dippel1,
  5. Peter J Koudstaal1,
  6. Evy G Visch-Brink1
  1. 1Department of Neurology, Erasmus MC University Medical Centre, Rotterdam, The Netherlands
  2. 2Department of Public Health, Erasmus MC University Medical Centre, Rotterdam, The Netherlands
  3. 3Rotterdam Neurorehabilitation Research (RoNeRes), Rijndam Rehabilitation Centre, Rotterdam, The Netherlands
  4. 4Department of Rehabilitation Medicine, Erasmus MC University Medical Centre, Rotterdam, The Netherlands
  1. Correspondence to Hanane El Hachioui, Erasmus MC University Medical Centre, Department of Neurology, Room EE 2291, PO Box 2040, 3000 CA Rotterdam, The Netherlands; h.hachiouiel{at}


Background The long-term functional outcome of aphasia after stroke is uncertain, even though this information is needed as early as possible for adequate patient care and support. This observational prospective study was aimed at predicting functional outcome at 1 year after stroke.

Methods We examined linguistic components (ScreeLing) and functional verbal communication (Aphasia Severity Rating Scale, ASRS) in 147 aphasic patients. The ScreeLing was administered at 1, 2 and 6 weeks after stroke; the ASRS at 1 week and 1 year. The relationships between linguistic, demographic and stroke characteristics, and good functional outcome at 1 year (ASRS 4 or 5) were examined with logistic regression analyses.

Results The baseline linguistic components (ie, semantics, phonology and syntax) were significant predictors (p<0.001) for 1-year outcome in univariable analyses. In multivariable analysis, these variables explained 46.5% of the variance, with phonology being the only significant predictor (p=0.003). Age, Barthel Index score, educational level and haemorrhagic stroke were identified as other significant predictors of outcome. A prognostic model of these five baseline predictors explained 55.7% of the variance. The internally validated area under the receiver operating characteristic curve (AUC) was 0.89, indicating good predictive performance. Adding the degree of phonological recovery between 1 and 6 weeks after stroke to this model increased the explained variance to 65% and the AUC to 0.91.

Conclusions The outcome of aphasia at 1 year after stroke can be predicted in the first week by the phonology score, the Barthel Index score, age, educational level and stroke subtype, with phonology being the strongest predictor.

  • Stroke
  • Rehabilitation
  • Speech Therapy
  • Cerebrovascular Disease

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