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Aspirin for acute migraine headaches in adults
  1. Varo Kirthi1,
  2. Sheena Derry2,
  3. R Andrew Moore2,
  4. Henry McQuay2
  1. 1Royal College of Physicians, London, UK
  2. 2Pain Research, Nuffield Department of Clinical Neurosciences (Nuffield Division of Anaesthetics), University of Oxford, Oxford, UK
  1. Correspondence to Dr Varo Kirthi, Clinical Fellow to the President, Royal College of Physicians, 11 St Andrew Place Regent's Park, London NW1 4LE, UK; varo.kirthi{at}

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A single oral dose of aspirin 900 mg or 1000 mg is more effective than placebo at resolving migrainous headache pain at 2 h and providing relief that is sustained over 24 h.1 Co-administration of metoclopramide 10 mg may provide additional pain relief and a greater reduction in associated symptoms, especially nausea.1


Migraine is a common, disabling, headache disorder, with considerable social and economic impact on the individual and society. Despite experiencing a high level of disability, most migraine sufferers do not seek professional …

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