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Research paper
The Val158Met COMT polymorphism is a modifier of the age at onset in Parkinson's disease with a sexual dimorphism

Authors

  • Stephan Klebe INSERM, UMR_S975, CR-ICM, Paris, France UPMC University Paris 06, UMR_S975, CR-ICM, Pitié-Salpêtrière Hospital, Paris, France CNRS UMR 7225, CR-ICM, Pitié-Salpêtrière Hospital, Paris, France Assitance Publique Hôpitaux de Paris, Département de Génétique et Cytogénétique, Hôpital de la Pitié-Salpêtrière, Paris, France INSERM, CIC-9503, Hôpital de la Pitié-Salpêtrière, Paris, France Assistance Publique Hôpitaux de Paris, Department of Neurology, Hôpital de la Pitié-Salpêtrière, Paris, France Department of Neurology, University Hospital Würzburg, Würzburg, Germany PubMed articlesGoogle scholar articles
  • Jean-Louis Golmard Assistance Publique Hôpitaux de Paris, Department of Biostatistics, Hôpital de la Pitié-Salpêtrière, Paris, France PubMed articlesGoogle scholar articles
  • Michael A Nalls Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda Maryland, USA PubMed articlesGoogle scholar articles
  • Mohamad Saad INSERM U1043, CPTP, Toulouse, France Paul Sabatier University, Toulouse, France PubMed articlesGoogle scholar articles
  • Andrew B Singleton Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda Maryland, USA PubMed articlesGoogle scholar articles
  • Jose M Bras Department of Molecular Neuroscience, UCL Institute of Neurology, London, UK PubMed articlesGoogle scholar articles
  • John Hardy Department of Molecular Neuroscience, UCL Institute of Neurology, London, UK PubMed articlesGoogle scholar articles
  • Javier Simon-Sanchez Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda Maryland, USA Department of Clinical Genetics Section of Medical Genomics, VU Medical Center, Amsterdam, Netherlands PubMed articlesGoogle scholar articles
  • Peter Heutink Department of Clinical Genetics Section of Medical Genomics, VU Medical Center, Amsterdam, Netherlands PubMed articlesGoogle scholar articles
  • Gregor Kuhlenbäumer Institute of Experimental Medicine, Christian-Albrechts University, Kiel, Germany PubMed articlesGoogle scholar articles
  • Rim Charfi Assistance Publique Hôpitaux de Paris, Department of Pharmacology, Hôpital de la Pitié-Salpêtrière, Paris, France Faculté de Médecine de Tunis, Université de Tunis El Manar, Centre National de Pharmacovigilance de Tunis, Service de Pharmacologie Clinique, Tunis, Tunisia PubMed articlesGoogle scholar articles
  • Christine Klein Institute of Neurogenetics, University of Lübeck, Lübeck, Germany PubMed articlesGoogle scholar articles
  • Johann Hagenah Institute of Neurogenetics, University of Lübeck, Lübeck, Germany PubMed articlesGoogle scholar articles
  • Thomas Gasser Department of Neurodegenerative Diseases, Hertie-Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany Department of Neurodegenerative Diseases, German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany PubMed articlesGoogle scholar articles
  • Isabel Wurster Department of Neurodegenerative Diseases, Hertie-Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany Department of Neurodegenerative Diseases, German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany PubMed articlesGoogle scholar articles
  • Suzanne Lesage INSERM, UMR_S975, CR-ICM, Paris, France UPMC University Paris 06, UMR_S975, CR-ICM, Pitié-Salpêtrière Hospital, Paris, France CNRS UMR 7225, CR-ICM, Pitié-Salpêtrière Hospital, Paris, France PubMed articlesGoogle scholar articles
  • Delia Lorenz Department of Neurology, UKS-H, Campus Kiel; Christian-Albrechts-University, Kiel, Germany PubMed articlesGoogle scholar articles
  • Günther Deuschl Department of Neurology, UKS-H, Campus Kiel; Christian-Albrechts-University, Kiel, Germany PubMed articlesGoogle scholar articles
  • Franck Durif Hôpital Gabriel Montpied, CHU de Grenoble, Department of Neurology, Clermont-Ferrand, France PubMed articlesGoogle scholar articles
  • Pierre Pollak CHU de Grenoble, Department of Neurology, Grenoble, France PubMed articlesGoogle scholar articles
  • Philippe Damier CHU de Nantes, Centre d'Investigation Clinique, Nantes, France PubMed articlesGoogle scholar articles
  • François Tison Hôpital Haut-Lévêque, Department of Neurology, Pessac, France PubMed articlesGoogle scholar articles
  • Alexandra Durr INSERM, UMR_S975, CR-ICM, Paris, France UPMC University Paris 06, UMR_S975, CR-ICM, Pitié-Salpêtrière Hospital, Paris, France CNRS UMR 7225, CR-ICM, Pitié-Salpêtrière Hospital, Paris, France Assitance Publique Hôpitaux de Paris, Département de Génétique et Cytogénétique, Hôpital de la Pitié-Salpêtrière, Paris, France PubMed articlesGoogle scholar articles
  • Philippe Amouyel INSERM, U744, Lille, France Institut Pasteur de Lille, Lille, France Université Lille-Nord de France, Lille, France PubMed articlesGoogle scholar articles
  • Jean-Charles Lambert INSERM, U744, Lille, France Institut Pasteur de Lille, Lille, France Université Lille-Nord de France, Lille, France PubMed articlesGoogle scholar articles
  • Christophe Tzourio Université Pierre et Marie Curie—Paris 6, CNRS 7225 CRICM, ER4-UPMC Modélisation en recherche clinique, Hôpital Pitié-Salpêtrière, Paris, France INSERM UMR_S708, Neuroépidémiologie, Paris, France PubMed articlesGoogle scholar articles
  • Cécilia Maubaret INSERM U897, Université Bordeaux Ségalen, Bordeaux, France PubMed articlesGoogle scholar articles
  • Fanny Charbonnier-Beaupel INSERM, UMR_S975, CR-ICM, Paris, France UPMC University Paris 06, UMR_S975, CR-ICM, Pitié-Salpêtrière Hospital, Paris, France CNRS UMR 7225, CR-ICM, Pitié-Salpêtrière Hospital, Paris, France PubMed articlesGoogle scholar articles
  • Khadija Tahiri INSERM, UMR_S975, CR-ICM, Paris, France UPMC University Paris 06, UMR_S975, CR-ICM, Pitié-Salpêtrière Hospital, Paris, France CNRS UMR 7225, CR-ICM, Pitié-Salpêtrière Hospital, Paris, France PubMed articlesGoogle scholar articles
  • Marie Vidailhet UPMC University Paris 06, UMR_S975, CR-ICM, Pitié-Salpêtrière Hospital, Paris, France CNRS UMR 7225, CR-ICM, Pitié-Salpêtrière Hospital, Paris, France Assistance Publique Hôpitaux de Paris, Department of Neurology, Hôpital de la Pitié-Salpêtrière, Paris, France “Movement Disorders and Basal Ganglia: Pathophysiology and experimental Therapeutics”, INSERM, UMR_S975, Paris, France PubMed articlesGoogle scholar articles
  • Maria Martinez INSERM U1043, CPTP, Toulouse, France Paul Sabatier University, Toulouse, France PubMed articlesGoogle scholar articles
  • Alexis Brice INSERM, UMR_S975, CR-ICM, Paris, France UPMC University Paris 06, UMR_S975, CR-ICM, Pitié-Salpêtrière Hospital, Paris, France CNRS UMR 7225, CR-ICM, Pitié-Salpêtrière Hospital, Paris, France Assitance Publique Hôpitaux de Paris, Département de Génétique et Cytogénétique, Hôpital de la Pitié-Salpêtrière, Paris, France Assistance Publique Hôpitaux de Paris, Department of Neurology, Hôpital de la Pitié-Salpêtrière, Paris, France PubMed articlesGoogle scholar articles
  • Jean-Christophe Corvol INSERM, UMR_S975, CR-ICM, Paris, France UPMC University Paris 06, UMR_S975, CR-ICM, Pitié-Salpêtrière Hospital, Paris, France CNRS UMR 7225, CR-ICM, Pitié-Salpêtrière Hospital, Paris, France INSERM, CIC-9503, Hôpital de la Pitié-Salpêtrière, Paris, France Assistance Publique Hôpitaux de Paris, Department of Pharmacology, Hôpital de la Pitié-Salpêtrière, Paris, France PubMed articlesGoogle scholar articles
  • French Parkinson's Disease Genetics Study Group and the International Parkinson's Disease Genomics Consortium (IPDGC)
    Google scholar articles
  1. Correspondence to Dr Jean-Christophe Corvol, Centre d'Investigation Clinique, Institut du Cerveau et de la Moelle épinière, Hôpital de la Pitié-Salpêtrière, 47 boulevard de l'Hôpital, Paris 75651 Cedex 13, France; jean-christophe.corvol{at}psl.aphp.fr.
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Citation

Klebe S, Golmard J, Nalls MA, et al
The Val158Met COMT polymorphism is a modifier of the age at onset in Parkinson's disease with a sexual dimorphism

Publication history

  • Received November 5, 2012
  • Revised January 4, 2013
  • Accepted January 7, 2013
  • First published February 13, 2013.
Online issue publication 
May 07, 2013

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