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Fasciculation potentials (FPs) are a spontaneous discharge of a motor units, frequently, but not invariably, visible as a muscle contraction.1 There are probably different neural generators involved, from the motor cortex to the distal nerve terminal, which differs depending on the associated neuromuscular disease.2 FPs bear special relevance to amyotrophic lateral sclerosis (ALS), a disease in which FPs are frequently generalised and profuse, associated with muscle cramping, and may even precede the development of lower motor neuron dysfunction. Indeed, absence of clinical and electrophysiologically recorded FPs raises concern about the diagnosis of …
Competing interests None.
Provenance and peer review Commissioned; internally peer reviewed.