Article Text

Download PDFPDF
Time to onset of secondary progression as an outcome in MS trials: a new paradigm?
  1. Bruce V Taylor
  1. Correspondence to Professor Bruce V Taylor, Menzies Research Institute University of Tasmania, Menzies Research Institute Private Bag 23, Hobart, Tasmania 7001, Australia; bruce.taylor{at}

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

Quantifying progression and delineating the onset of progression in multiple sclerosis (MS) have been subjects of considerable debate over many years. Particularly, as the current standard measures of disability, such as the expanded disability status scale (EDSS)1, lack linearity or responsiveness to change and do not define progression onset. Scalfari et al2 discuss the utility of time to secondary progressive MS as a potential outcome measure in MS and provide significant information on the factors that predict this milestone in MS disease course.

They raise several important and sometimes controversial points, none more contentious than the role of relapses in the development of progression. They find that early relapses within the first 2 years do significantly influence the timing of onset …

View Full Text


  • Competing interests None.

  • Provenance and peer review Commissioned; externally peer reviewed.

Linked Articles