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Apathy is one of the most disabling behavioural disorders in Parkinson's disease (PD). It corresponds to a set of behavioural, emotional and cognitive features, such as reduced interest and participation in the main activities of daily living, a lack of initiative, a trend towards early withdrawal from initiated activities, indifference and flattening of affect. Its prevalence in PD ranges from 17% to 70%.1 This broad variability is related to heterogeneous population characteristics (the general population, patients in specialist departments, institutionalised patients, etc), different assessment procedures (clinical assessments, scores on non-specific or specific scales, etc) and the overlap between the clinical manifestations of apathy and those of other disorders (such as depression, anhedonia, cognitive decline and even some personality traits). The mechanisms that …
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Provenance and peer review Commissioned; internally peer reviewed.
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