You are here

Article Text

Article menu

Download PDFPDF

Neurodegeneration
Review
Cerebrospinal fluid biomarkers in parkinsonian conditions: an update and future directions
  1. Nadia Magdalinou1,
  2. Andrew J Lees1,
  3. Henrik Zetterberg1,2
  1. 1Department of Molecular Neuroscience, UCL Institute of Neurology, London, UK
  2. 2Clinical Neurochemistry Laboratory, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden
  1. Correspondence to Dr Nadia Magdalinou, Reta Lila Weston Institute, UCL Institute of Neurology, 1 Wakefiled Street, London WC1N 1PJ, UK; n.magdalinou{at}ucl.ac.uk

Abstract

Parkinsonian diseases comprise a heterogeneous group of neurodegenerative disorders, which show significant clinical and pathological overlap. Accurate diagnosis still largely relies on clinical acumen; pathological diagnosis remains the gold standard. There is an urgent need for biomarkers to diagnose parkinsonian disorders, particularly in the early stages when diagnosis is most difficult. In this review, several of the most promising cerebrospinal fluid candidate markers will be discussed. Their strengths and limitations will be considered together with future developments in the field.

  • CSF
  • Parkinson's Disease
  • Progressive Supranuclear Palsy
  • Multiple System Atrophy
  • Corticobasal Degeneration

This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 3.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/3.0/

http://dx.doi.org/10.1136/jnnp-2013-307539

Statistics from Altmetric.com

    View Full Text

    Request Permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

    Copyright information:

    Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 3.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/3.0/