Article Text

Download PDFPDF
Protein kinase C polymorphisms and vitamin D levels in multiple sclerosis
  1. Murali Ramanathan
  1. Correspondence to Professor Murali Ramanathan, State University of New York, Buffalo, 355 Kapoor Hall, Buffalo, NY 14214, USA; murali{at}

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

Epidemiological evidence suggests that low levels of serum vitamin D are a possible risk factor for the development of multiple sclerosis (MS).1 The exact mechanisms by which vitamin D exerts its effects on MS risk are not well understood. The paper by Lin et al2 identifies novel protein kinase C polymorphisms associated with 25 hydroxy vitamin D levels in MS patients.

Vitamin D is derived from the diet and from endogenous production in the skin. Vitamin D is akin to a pro-drug: it must be hydroxylated to the 25 hydroxy vitamin D metabolite in the liver and then to the active 1, 25 dihydroxy vitamin D form that binds the vitamin D receptor. Several cytochrome P450 enzymes including CYP2R1, CYP2D11 and CYP2D25 can catalyse the 25-hydroxylation reaction3 …

View Full Text


  • Competing interests None.

  • Provenance and peer review Commissioned; internally peer reviewed.

Linked Articles