Article Text

Download PDFPDF
The clinical relevance of voltage gated potassium channel (VGKC)-complex antibodies: the story is still unfolding
  1. Susanna B Park
  1. Correspondence to Dr S B Park, Institute of Neurology, University College London, London WC1N 3BG, UK; Susanna.park{at}

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

An increasingly broad spectrum of neurological disorders have been associated with voltage gated potassium channel (VGKC)-complex antibodies, including peripheral nerve hyperexcitability, Morvan's syndrome, limbic encephalitis, epilepsy and, more recently, idiopathic pain and psychiatric disorders. Over the past several years, there have been great leaps in our understanding of VGKC autoimmunity, including identification of specific antigenic targets in VGKC associated proteins.1 ,2 Several specific targets of VGKC-complex associated antibodies have now been identified, including the cell surface antigens leucine-rich glioma inactivated 1 (LGI1) and contactin associated protein 2 (CASPR2).1 ,2 Antibodies to LGI1 are associated with predominantly …

View Full Text


  • Competing interests None.

  • Provenance and peer review Commissioned; not externally peer reviewed.

Linked Articles