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Research paper
Resting-state fMRI study on drug-naive patients with Parkinson's disease and with depression
  1. ChunYan Luo1,
  2. Qin Chen1,
  3. Wei Song1,
  4. Ke Chen1,
  5. XiaoYan Guo1,
  6. Jing Yang1,
  7. XiaoQi Huang2,
  8. QiYong Gong2,
  9. Hui-Fang Shang1
  1. 1Department of Neurology, West China Hospital, SiChuan University, Chengdu, Sichuan, China
  2. 2Department of Radiology, Huaxi MR Research Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China
  1. Correspondence to Professor Hui-Fang Shang, Department of Neurology, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China; hfshang2002{at}


Objective This study used resting-state functional MRI (fMRI) to evaluate regional and network alterations in patients with Parkinson's disease (PD) with and without depression.

Method We recruited 29 patients with PD with depression (PD-Dep), 30 patients with PD without depression (PD-NDep), and 30 normal controls. All participants underwent resting-state fMRI scans on a 3-T MR system. The amplitude of low-frequency fluctuation (ALFF) of blood oxygen level-dependent signals was used to characterise regional cerebral function. Functional integration of the brain network was evaluated by seed-based correlation approach.

Results The PD-Dep group showed significantly higher ALFF value in the left orbitofrontal area compared with both the PD-NDep and control groups (p<0.05 corrected by FWE). In patients with PD, the Hamilton Depression Rating Scale score was positively correlated with the ALFF value in the left orbitofrontal cortex (p<0.005 uncorrected). Brain network connectivity analysis revealed reduced functional connectivity of putamen in both PD subgroups. However, the PD-Dep group showed more distributed reduced connectivity in the prefrontal-limbic network than the PD-NDep group did (p<0.05 corrected by FWE).

Conclusions Our study demonstrates that PD-Dep patients are characterised by increased regional spontaneous neural activity in the orbitofrontal area and decreased functional integration within the prefrontal-limbic network. These findings may be helpful for facilitating further understanding of the potential mechanisms underlying depression in PD.

  • Parkinson's Disease
  • Depression
  • Functional Imaging

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