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The recently published article by Paganini et al1 report the clinical outcomes of 10 patients with Huntington's disease (HD) receiving fetal grafting in the striatum, and compared with 16 non-grafted HD controls. The authors assessed the transplantation effect through a model of change in slope (disease progression over time) following grafting, a reduced deterioration in motor scores of −2.0 units/year was observed compared with the pretransplantation period and non-transplanted patients, with chorea and ocular movements achieving the highest benefit.1 Importantly, the slope of cognitive deterioration was also reduced. The present study adds important evidence to support transplantation of fetal tissue in patients with HD, although the observed benefit seems to be modest. The authors calculated that to worse 30 …
Competing interests None.
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Provenance and peer review Commissioned; internally peer reviewed.
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