Enroll-HD is a longitudinal observational study of Huntington’s disease that functions as a registry of potential participants for clinical trials. Investigators are encouraged to recruit as many of their HD patients and pre-symptomatic gene expansion carriers as possible into Enroll-HD allowing visibility to participant clinical data that can be used to determine potential eligibility for clinical trial inclusion. Managing the workflow for hundreds of participants in Enroll-HD at sites can be challenging. This educational session will explore a variety of strategies that work at existing sites to organise and manage research staff responsibilities and participant through-put in a busy Enroll-HD clinic. The session will be interactive and through sharing of ideas and practical strategies participants will develop plans that can be implemented at their site.