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In 2011, a case was reported in which a patient with multiple sclerosis (MS) and HIV was treated with antiretroviral therapy (ART)—he did not experience MS-related deficits for over a decade.1 This prompted researchers in Denmark (Nexø et al) to examine the association between MS and HIV using population-based databases. Although they found a reduced incidence of MS in HIV-positive individuals compared with the general population, their study did not achieve a conventional level of statistical significance.2 I was recently asked to review the Gold et al study,3 which has answered the Danish researchers’ call for a larger study to investigate whether HIV, or its treatment, has a protective effect on the development of MS.
Similar to the original Danish study, Gold et al used administrative health databases to fulfil their research objectives; in …
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