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Research paper
HIV and lower risk of multiple sclerosis: beginning to unravel a mystery using a record-linked database study
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  • Published on:
    HIV and lower risk of multiple sclerosis: protective or subjugating effect?
    • Tatiana Koudriavtseva, Head of Multiple Sclerosis Center
    • Other Contributors:
      • Domenico Plantone, Paola Cordiali-Fei

    Dear Sirs, Gold and colleagues recently found a significantly decreased risk of developing multiple sclerosis (MS) after the onset of HIV infection in a large cohort of national linked data set of English Hospital Episode Statistics.(1) The possible causes of this negative association have been hypothesized to be immunodeficiency and antiretroviral treatment (ART) as MS is usually treated with immunosuppressive drugs and...

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    Conflict of Interest:
    None declared.
  • Published on:
    Re:How accurate is the record linkage?

    We thank Dr. Voci for his comments[1] on our article.[2] As described in the paper, our data comprise Hospital Episode Statistics (HES) obtained from the English national Health and Social Care Information Centre (HSCIC) and mortality record abstracts obtained from the Office for National Statistics. All data from both sources were anonymised to the same standard by encryption of personal identifiers before being supplied...

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    Conflict of Interest:
    None declared.
  • Published on:
    How accurate is the record linkage?

    This is an interesting study. However, I am somewhat concerned whether the record linkage could be appropriately performed. In most healthcare information systems, HIV patients characteristics are protected. Did the authors have enough information on the patients to perform probabilistic matching? It would be of interest if the authors could show that the matching is adequate by showing that there is not a general reduce...

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    Conflict of Interest:
    None declared.